9th Annual Symposium on Antiviral Drug Resistance: Targets and Mechanisms





In the schedule below, click on a session title to go to that particular session.  Abstracts of the talks and posters have been posted here beginning November 16, 2008.  Keynote talks are designated with an asterisk.

SUNDAY, NOV. 16 6:00 - 7:35 pm Session 1:  Introduction and Overviews
MONDAY, NOV. 17 8:30 - 10:10 am Session 2:  Viral Entry
10:40 am - 5:50 pm Session 3:  Nucleic Acid Replication
6:00 - 7:30 pm Poster Session
TUESDAY, NOV. 18 8:30 am - 2:20 pm Session 4:  Assembly, Release, and Processing
2:20 - 5:50 pm Session 5:  Novel Antiviral Strategies
6:00 - 7:30 pm Poster Session
WEDNESDAY, NOV. 19 8:30 am - 12:00 noon Session 6:  Biology of Viral Infection



SUNDAY, NOVEMBER 16

Session 1:  Introduction and Overviews
Session 1:  (Chair, Stephen Hughes)

Jeffrey Strathern
Welcoming Remarks

* W. Ian Lipkin
Microbe Hunting in the 21st Century (Abstract)

* Derek Smith
The Global Evolution and Circulation of Influenza Viruses (Abstract)


MONDAY, NOVEMBER 17

Session 2:  Viral Entry
Session 2:  (Chair, Rahm Gummuluru)

* Olivier Schwartz
Novel Insights into Mechanisms of HIV Cell-to-Cell Transfer: Role of "Polysynapses" (Abstract)

Christos Petropoulos
Co-receptor Utilization and env Sequence in Recent CXCR4-Tropic HIV-1 Infection (Abstract)

* Michael Rossmann
Peptide Inhibitors of Dengue and West Nile Virus Infectivity (Abstract)


Yutaka Takebe
Potent Inhibition of HCV Entry by Carbohydrate Binding Proteins (Abstract)

Session 3:  Nucleic Acid Replication
Session 3:  (Co-Chairs, Stefan Sarafianos and Kirsten White)

* Paul Ahlquist
Virus and Host Functions in RNA Virus Replication (Abstract)

* Max Nibert
The Reovirus Platform: Nonstructural Protein NS and Its Multiple Roles in Viral Factories (Abstract)

* Eddy Arnold
Complementary Mechanisms of Nucleoside Analog Resistance from Structural Studies of HIV-1 Reverse Transcriptase (Abstract)

Michael Abram
Fidelity of HIV-1 Reverse Transcriptase: The "Truth" Is out There…In Vivo! (Abstract)

Dwight Nissley
Fidelity of HIV-1 Reverse Transcription: RT Variants with Increased Levels of Mutation (Abstract)

* Nicolas Sluis-Cremer
Discovery, Structure-Activity-Resistance Relationships and Pharmacology of the 3'-Azido-2',3'-Dideoxypurines, a Potent Lead Class of Nucleoside Analogs Active against Drug-Resistant HIV-1 (Abstract)

Eleftherios Michailidis
Hypersensitivity of K65R HIV-1 Reverse Transcriptase to 4'-Ethynyl-2-Fluoro Deoxyadenosine (EFdA) (Abstract)

Michaela Wendeler
New Lessons from HIV RNase H Inhibitors (Abstract)

Kyeongeun Lee
Regulation of HIV-1 Nuclear Import (Abstract)

Mamuka Kvaratskhelia
The Highly Dynamic Structure of Multimeric HIV-1 Integrase as a Novel Therapeutic Target (Abstract)

Henry Levin
Retrotransposon Tf1 Is Targeted to Pol II Promoters by Transcription Activators (Abstract)

* Alan Frankel
Assembly of Tat and Rev Complexes (Abstract)

Kevin Weeks
The Structure of an Entire HIV-1 RNA Genome (Abstract)

* Graham Hatfull
The Big Wide World of Bacteriophages: What Are They and How Did They Get to Be That Way? (Abstract)

Poster Session


TUESDAY, NOVEMBER 18

Session 4:  Assembly, Release, and Processing
Session 4:  (Co-Chairs, Mamuka Kvaratskhelia and Christos Petropoulos)

Olga Nikolaitchik
Trafficking and Dimerization of HIV-1 RNA: Investigations into Its Subcellular Localization and Export Requirements (Abstract)

Susana Valente
Inhibition of HIV-1 mRNA 3' End Cleavage by eIF3f (Abstract)

* Eric Poeschla
Simultaneous Imaging of Lentiviral Genomic RNA and Gag in Live Cells: Deciphering the Cell Biology of Encapsidation (Abstract)

* James Hurley
HIV-1 Budding and the ESCRT Complexes (Abstract)

Meng Sun
Retrovirus-Specific Differences in Protein-Nucleic Acid Interactions: Implications for Genomic RNA Packaging (Abstract)

Rachael Crist
Assembly Properties of HIV-1 Gag-Leucine Zipper Chimeras: Implications for Retroviral Assembly (Abstract)

John Purdy
Defining the Nucleation Step of Early Capsid Assembly (Abstract)

Benjamin Luttge
FIV Resistance to a Dominant-Negative Fragment of Tsg101 Maps to the Env Glycoprotein (Abstract)

* Juan Bonifacino
Mechanisms of CD4 Downregulation by the Nef Protein of Immunodeficiency Viruses (Abstract)

François Clavel
Differential Effect of Gag Determinants on Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors and Replicative Capacity (Abstract)

* John E. Johnson
Designer Virus Particles as Multi-Valent Presentation Systems for Polypeptide and Protein Antigens (Abstract)

Session 5:  Novel Antiviral Strategies
Session 5:  (Co-Chairs, Henry Levin and Daria Hazuda)

* Paul Bieniasz
Tetherin, an Interferon-alpha Induced Inhibitor of Retrovirus Release That Is Antagonized by Vpu (Abstract)

Vinay Pathak
Distinct Domains within APOBEC3G and APOBEC3F Interact with Separate Regions of HIV-1 Vif (Abstract)

Gisela Heidecker
Retrovirus Resistance to APOBEC3 Restriction (Abstract)

Linda Chelico
Crystal Structure of the Anti-Viral APOBEC3G Catalytic Domain (CD2) and Its Functional Implications (Abstract)

* Michael Emerman
The Evolutionary Dynamics of APOBEC3 Function (Abstract)

* Abraham Brass
Using Functional Genomics to Find Host Proteins Required for HIV Replication (Abstract)

* Sumit Chanda
Global Analysis of Host-Pathogen Interactions That Regulate Early HIV-1 Replication (Abstract)

Poster Session


WEDNESDAY, NOVEMBER 19

Session 6:  Biology of Viral Infection
Session 6:  (Co-Chairs, François Clavel and Jonathan Stoye)

* Rolf Renne
KSHV-Encoded Micro-RNAs and Their Potential Role in Viral Biology and Pathogenesis (Abstract)

* Kanta Subbarao
Active and Passive Immunization against Avian Influenza Viruses (Abstract)

* Theodora Hatziioannou
Restriction Factors to HIV-1 Replication in Macaques (Abstract)

* Gary Nabel
AIDS Vaccines at a Crossroads: What Might the Future Hold? (Abstract)

Jason Dinoso
Treatment Intensification Does Not Reduce Residual HIV-1 Viremia in Patients on Highly Active Antiretroviral Therapy (Abstract)

Helene Mens
Single Genome Sequence Analysis of Plasma Viruses from HIV-1 Controllers Suggests Ongoing Low-level Replication (Abstract)

Yoshihiro Kitamura
Variants of JFH1 Strain of Hepatitis C Virus, Which Have Adapted to Cultured Huh7 Cells (Abstract)

John Coffin
Closing Remarks




Home
Welcome | Important Dates | Invited Speakers | Scientific Program | General Information
Participation Support | Abstract Submission | Registration | Sponsors | Contact